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What is a setback?

What is a setback? Here are some definitions.

Noun
  1. An obstacle, delay, or disadvantage.
  2. (US) The required distance between a structure and a road.
  3. (architecture) A step-like recession in a wall.
  4. (possibly archaic) A backset; a countercurrent; an eddy.
  5. A backset; a check; a repulse; a relapse.
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Examples
This was apparently yet another significant setback to the dissident republican cause.
Suffering setback after setback, he is currently back in Rio recuperating from his latest.
It was an unfortunate setback after a period of relative stability and noticeable improvement.
His only consolation is that each setback provides ammunition for his songwriting.
The olive ridley turtle is one of several animal species that may have suffered a big setback as a result of last month's earthquake and tsunami.
But he doesn't seem to be worried about the loss of earnings and career setback that most female returners experience.

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