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What is drug abuse?

What is drug abuse? Here are some definitions.

Noun
  1. Misuse of, or overindulgence in, drugs; substance abuse. [from 20th c.]
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For some, alleviation of the drug abuse problem will serve to reduce related criminal behavior.
Parental alcoholism, drug abuse, mental instability, and severe domestic violence resulted in feelings of emotional abandonment, as well.
Adolescent drug abuse co-occurs with other clinical problems with alarming frequency.
The canine cops were introduced in a bid to prevent drug abuse as well as possible trafficking of illegal drugs on in-patient units.
Everybody there had issues from child abandonment to drug abuse, but I got used to it and just stayed to myself.
Many writers have tried to poeticize drug abuse, to portray their habits as fanciful rather than merely destructive.

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