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What is a bolus?

What is a bolus? Here are some definitions.

Noun
  1. A round mass of something, especially of chewed food in the mouth or alimentary canal.
  2. A single, large dose of a drug, especially one in that form.
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Examples
The process of deglutition begins with the bolus formation in the oral cavity.
Patients may succeed in passing the food bolus by repeated swallowing, by performing the Valsalva maneuver or by making a positional change.
The cardiac sphincter opens because of increasing pressure in the esophagus from the food bolus.
For an allergic person, a small amount of caffeine acts like a bolus, generating abnormal psychological response, including mania.
Another factor that may limit uptake of the radiopharmaceutical is the transient nature of the tracer bolus presented to the cells in vivo.
On Midway Island in the Hawaiian chain, a bolus, or mass of chewed food, coughed up by one bird included many identifiable objects.

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