| The inhibitory compounds used for study are cytotoxic themselves, resulting in effects that are irreversible. |
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| Earlier studies indicated that the fibrils themselves were the cytotoxic form of amyloid peptides. |
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| The ability to distinguish between the two cell types is not complete, and cytotoxic drugs cannot avoid causing some damage to normal cells. |
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| This reaction results in the production of oxygen radicals, which are cytotoxic to the tumor cells. |
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| A woman was exposed to a possible teratogen such as a live vaccine or cytotoxic drug when she was not protected by effective contraception. |
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| Ganciclovir is a guanosine analog that becomes strongly cytotoxic when phosphorylated. |
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| The control experiment with ascorbate alone shows no noticeable cytotoxic action of sodium ascorbate. |
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| The catalytic antibody technology can localize the delivery of a cytotoxic drug to a specific cell or cancer type. |
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| A wide variety of agents has been discovered that stabilize such structures and exert cytotoxic effects on cells in culture. |
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| The free radicals and reactive species produced by these reactions are highly cytotoxic. |
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| Leukocidin is a pore-forming protein that has cytotoxic effects on host cells. |
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| Unsaturated aldehydes are often cytotoxic, and many of them are precursors of fluorescent products. |
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| Pores in membranes can be induced by cytotoxic peptide antibiotics and by peptide fragments of viral glycoproteins. |
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| The fibrils formed by the hexapeptide were also cytotoxic toward the pancreatic cell line. |
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| In vitro, these peptides inhibited cytotoxicity and differentiation of cytotoxic T cells. |
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| Physician office laboratories that handle cytotoxic drugs are required to have special procedures for handling these agents. |
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| The septicaemic isolates were observed to produce cytotoxic changes in high dilutions of culture filtrate. |
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| Nurses usually prepared and administered intravenous drugs on the wards, but cytotoxic drugs were prepared centrally by the pharmacy department. |
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| She was subjected to an intensive combination of cytotoxic drugs and cranial radiotherapy. |
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| The remainder, which includes body parts and the cytotoxic material, will be incinerated abroad. |
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| The benefit of cytotoxic agents such as cyclophosphamide has not yet been established. |
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| Drug treatment of cancer is often limited by unwanted tissue damage due to the lack of tumor selectivity of the cytotoxic agents administered. |
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| The Company has established a proof-of-concept with doxorubicin, a cytotoxic drug, showing its efficient delivery in animal solid tumor models. |
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| An isolator intended for asepsis and containment of cytotoxic residue was reported by one respondent in Atlantic Canada. |
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| The first proof-of-concept was demonstrated with a cytotoxic agent in both in-vitro and in-vivo animal models. |
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| A hospital doctor has been charged with manslaughter over the death of a teenager who was wrongly given a spinal injection of a cytotoxic drug meant for intravenous use only. |
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| It can be concluded that iodinated derivatives of hypericin do not show an increased cytotoxic effect upon irradiation in either monolayers or spheroids. |
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| Active cytotoxic agents for patients with advanced KS with the longest track records include vinca alkaloids, anthracyclines, bleomycin, and etoposide. |
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| Autolysed samples can be cytotoxic to the cell culture and consequently limit its use. |
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| Vitamin C is directly cytotoxic to certain cancer cell lines in vitro. |
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| There are two types of lymphocytes: helper or inducer lymphocytes and cytotoxic lymphocytes. |
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| With cellular immune response, specific cytotoxic T cells are formed. |
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| The authors further note that lymphopenia induced by cytotoxic chemotherapy or other insults can significantly diminish immune function. |
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| As with all cytotoxic chemotherapy, adequate contraceptive precautions should be used when either partner is receiving busulfan. |
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| Central venous catheters are used for haemodynamic monitoring, giving vasopressors and cytotoxic drugs, sampling blood, and giving fluids and parenteral nutrition. |
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| The production of a cytotoxic factor synthesized by human haemic killer cells growing in vitro is described. |
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| However, this dose is not sufficient for the cytotoxic substances to be also completely destroyed. |
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| The cell membrane contains transport proteins that translocate cytotoxic compounds toward the exterior of the cell. |
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| Dr. Chris Mody at the University of Calgary has found that two types of cells, called cytotoxic lymphocytes, are able to kill cryptococcus. |
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| Cancer cells may lose all class I MHC molecules from their surface, which prevents cytotoxic T cells from recognizing the cells. |
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| This recognition leads to the activation of cytotoxic T lymphocytes, which attack and kill the cell through the induction of apoptosis. |
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| The administration of cytotoxic agents may be required for patients in critical care areas. |
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| The Fas ligand is a key death factor of cytotoxic T lymphocytes and natural killer cells. |
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| Glutaraldehyde has often been used to chemically crosslink bioprosthetic heart valves but is quite cytotoxic. |
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| Tumorigenesis is a multifactorial and complex process involving multiple oncogenes and resulting in cancerous cells with specific proliferation capabilities as well as particular sensitivity to any given cytotoxic agent. |
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| As with other cytotoxic agents, thrombophlebitis and thromboembolic phenomena, including pulmonary embolism, have been coincidentally reported with the use of idarubicin. |
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| Disorazol Z is a novel natural compound, with outstanding cytotoxic activity, isolated from the myxobacterium Sorangium cellulosum. |
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| Such a vaccination has already demonstrated increased in-vivo clonal expansion and maintenance of adoptively transferred tumor-antigen specific cytotoxic lymphocytes in preclinical models. |
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| Overall reduction factors may be underestimated where production conditions or buffers are too cytotoxic or virucidal and should be discussed on a case-by-case basis. |
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| These include exposure to diathermy plumes, outdated guidelines for handling cytotoxic substances and standards for theatre crate weights. |
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| There have been reports of liver failure and death in patients with cancer receiving concurrent medications including potentially hepatotoxic cytotoxic chemotherapy and antibiotics. |
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| The efficacy of MMF and MPA in preventing cytotoxic cell generation provides the rationale for the prophylactic use of this drug to prevent rejection in allograft recipients. |
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| The principle of the reconstructed human epidermis model test is based on the premise that irritant substances are able to penetrate the stratum corneum by diffusion and are cytotoxic to the cells in the underlying layers. |
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| The required treatment for a snake bite is defined according to whether the venom is cytotoxic, haemotoxic or neurotoxic and the wrong treatment will not only be of little or no help but could even be dangerous. |
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| Mouse trials have shown strong antibody and cytotoxic T lymphocyte responses to peptide and protein antigens and protection in model systems of infection and cancer. |
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| Procedures that govern the use of cytotoxic medications for oncology indications are also applicable when medications such as cyclophosphamide are used for nononcology purposes. |
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| Macrophages are a first line of defense against pathogens and malignancies by nature of their phagocytic, cytotoxic, and intercellular killing capacities. |
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| The efficacy of anticancer treatments is nevertheless still generally based on the use of cytotoxic agents, targeted cancer therapies enabling amplification of the results obtained by these treatments. |
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| It will test a combination of the gp120 vaccine and one that stimulates cytotoxic lymphocytes. If the VaxGen trials turn out negative, gloom will descend with a vengeance. |
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| They point out that the antibodies induced naturally by HIV don't seem to do much good, and prefer the idea of stimulating another part of the immune system, cells known as cytotoxic lymphocytes which kill infected cells. |
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| In general, the granular cytotoxic T cells tend to kill cells directly by releasing the potent contents of their cytotoxic granules at the site of cell-to-cell contact. |
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| Refer to your institution's guidelines for disposal of cytotoxic waste. |
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| Natural killer cell cytotoxic activity increases acutely and proportionately with exercise intensity, and then returns to resting levels soon after brief to moderate exercise. |
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| You have to have a cytotoxic response to kill cells of other types. |
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| Individuals with liver disease or individuals receiving cytotoxic therapy or diuretics, were reported rarely to demonstrate a decrease in serum potassium concentrations with high doses of Piperacillin for Injection. |
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| The filters and prefilters must be disposed of with the cytotoxic waste. |
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| Ceptaris Therapeutics, developing mechlorethamine gel, a topically delivered cytotoxic agent to treat cutaneous T-cell lymphoma. |
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| The cytotoxic effect of snake venom is being researched as a potential treatment for cancers. |
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| Psammaplins, in particular psammaplin A have demonstrated cytotoxic properties. |
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| Synthesis of a new 4-aza2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents. |
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| Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba. |
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| Cell-mediated immunity does the job with a white blood cell called the killer, or cytotoxic, T cell. |
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| This allows the recombinant ribonucleases of this invention to be fused in-frame with ligand binding moieties to form cytotoxic fusion proteins. |
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| Specifically, the investigators examined the NK cell cytoskeleton during target cell killing in comparison to that of cytotoxic T cells. |
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| Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization. |
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| Cytotoxic activity of marine algae and a cytotoxic principle of the brown alga Sargassum tortile. |
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| Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. |
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| Emami discovered that polyphenols in a cigarette filter efficiently remove free radicals of cytotoxic molecules of cigarette smoke. |
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| Failure of infiltrating precursor cytotoxic T cells to acquire direct cytotoxic function in immunologically privileged sites. |
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| These single-minded killers, white blood cells called cytotoxic T cells, normally destroy only cells infected by viruses. |
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| Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone. |
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| To prove the cytotoxic efficacy of P estradiol in Jurkat T-cell model, cell viability was determined by the MTT assay. |
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| Use of estramustine in combination with other cytotoxic agents is not recommended due to the increased risk of clinically important toxicities. |
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| Methysticin was the most potent enzyme inhibitor as well as the most cytotoxic, followed by the kava root extract, desmethoxyyangonin, and yangonin. |
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| Furthermore, several compounds with antioxidant activity, such as methyl caffeate, have been isolated from BC, but none of these compounds are cytotoxic. |
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| In order to study the cytotoxic effect of the characteristic compounds of saffron spice, we have isolated crocin, crocetin, picrocrocin and safranal. |
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| In addition to stimulating B lymphocytes, Th2 cells suppress the cytotoxic T lymphocyte response, decreasing the robustness of cell-mediated immunity. |
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| Deb Kumar Chatterjee, has validated the biological activity of Cre recombinase and cytotoxic enzymes delivered using Virus-like Particles in a human prostate cancer cell line. |
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| Examples of drug-specific factors include their cytotoxic effect on cells, mechanisms of clearance, and concomitant use with other non-chemotherapeutic nephrotoxic agents. |
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| Finally, the cytotoxic properties of the synthesized compounds will be evaluated on site at the ICSN, which could ultimately lead to the discovery of new antitumoral products. |
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| Two nowel cytotoxic benzofuran derivatives from Brazilian propolis. |
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| It is speculated that the role of KIR expression on T cells is related to the ability to escape attack by cytotoxic T cells which react with autoantigens. |
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| Hydrocarbon poisoning such as that of benzene and petroleum usually occurs accidentally by inhalation or ingestion of these cytotoxic chemical compounds. |
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